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Hemoglobin SC DiseaseWhat is Hemoglobin SC Disease?Hemoglobin SC disease (Hb SC) is an inherited form of sickle cell disease that affects red blood cells. The most common types of sickle cell disease are SS, SC and S beta thalassemia. Hemoglobin SC disease affects one out of every 835 African-American babies. However, it is also common in people whose families are from South or Central America, the Caribbean Islands, Mediterranean countries and the Middle East. A person with hemoglobin SC disease has red blood cells that sickle. On average, individuals with hemoglobin SC disease have milder symptoms than those with sickle cell disease (hemoglobin SS disease). However, this is only on average and individuals with hemoglobin SC disease may have medical problems in equal severity to those with sickle cell disease including anemia (low hemoglobin), crises (painful episodes), organ damage, infections, lung problems, leg ulcers, bone damage and strokes. Hemoglobin SC disease is a lifelong condition and requires lifelong treatment. What is Hemoglobin?
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It is important to identify people who are carriers of abnormal hemoglobin so they will be aware of their risk of having children with sickle cell disease. If both parents are carriers of sickle cell trait or another hemoglobin change (like hemoglobin C), there is a 25 percent (or one in four) chance that they will have a child with sickle cell disease. The couple also has a 25 percent chance of having a child with regular hemoglobin (AA) and a 50 percent chance of having a child with a hemoglobin trait like the parents. It is recommended that people who carry a hemoglobin trait meet with a genetic counselor to obtain more information.  |
Illinois Department
of Public Health |